Blisphora by Metagenics provides 400 mg of SAMe (s-adenosyl-L-methionine) with 1,000 mcg of 5-MTHF folic acid ((6S)-5-methyltetrahydrofolic acid) and 1,000 mcg of vitamin B12 (methylcobalamin).
Science is not completely sure of every way that SAMe works to fight depression, but we do know that it is a universal methyl donor, offering it’s methyl groups to any other processes in the body that needs it. This is important because neurotransmitters that balance mood and behavior such as serotonin, dopamine, melatonin and epinephrine (adrenaline) and nor-epinephrine (nor-adrenaline) all require these methyl groups to be produced and to function.
Perhaps you’ve heard of epigenetics before? It’s the alteration of gene expression, or basically if a gene is turned on or off, without changing the DNA sequence. One way epigenetics is controlled is through methylation. For example, you could carry a gene that is seen more commonly in people who develop cancer, but methylation can control whether that gene is turned on or off. As you can guess, it is important to have the required ingredients in your body to be able to control methylation as needed. SAMe provides one of those major ingredients.
Two other major ingredients for methylation in the body are folate and vitamin B12. This formula contains significant doses of these too. Unfortunately, approximately 60% of the population has a genetic mutation called a polymorphism of the methylenetetrahydrofolate reductase (MTHFR) enzyme. Yes, that’s a mouthful! What you need to know is that regular folate does not work in these people, causing all sorts of problems such as elevated homocysteine levels, which in turn cause cardiovascular issues such as heart attack, stroke and has even been linked to Alzheimer’s disease. If you’re one of the 60%, it is very important to make sure you’re supplementing with an active form of vitamin B12 and folate, such as the (6S)-5-methyltetrahydrofolic acid (folate) and methylcobalamin (B12) found in Blisphora.
Blisphora is a powerful combination to support a healthy mood that provides the nutrients needed for adequate methylation, neurotransmitter production and internal SAMe production.
This product is gluten free, Non-GMO and vegetarian. Storage: Keep in a cool, dry place.
Ingredients
Folate [from (6S)-5-methyltetrahydrofolic acid, glucosamine salt] 1 mg, Vitamin B12 (as methylcobalamin) 1 mg, S-Adenosyl-L-Methionine (SAMe)(as SAMe disulfate p-toluensulfonate) 400 mg. Other Ingredients: Microcrystalline cellulose, magnesium stearate (vegetable), stearic acid (vegetable), silica, mannitol, carboxymethylstarch sodium salt, and coating (methacrylic acid copolymer, triethyl citrate, titanium dioxide, and silica).
| Ingredient | Amount | Daily Value |
| Serving Size | 1 Tablet | |
| Servings Per Container | 30 | |
| Folate [from (6S)-5-methyltetrahydrofolic acid, glucosamine salt] | 1000 mcg | 250% |
| Vitamin B12 (as methylcobalamin) | 1000 mcg | 16,667% |
| S-Adenosyl-L-Methionine (SAMe) (as SAMe disulfate p-toluensulfonate) | 400 mg | * |
Recommended Dosage (adult)
Directions: Take one tablet daily 30 minutes before a meal on an empty stomach with water or as directed by your healthcare practitioner.
Warnings:
- Warning: Do not use if pregnant or nursing.
- Caution: If you have a history of psychiatric disorders or if you are taking medications, please consult your healthcare practitioner prior to use. Keep out of the reach of children.
charlotte25.mason –
These work awesomely, but they are super expensive
georgemelson05 –
Have been using it for 2 years now and it really improves my state of mind.